Introduction
No study determined if vitamin D supplementation improves health-related quality of
life (HRQL) using pediatric Patient-Reported Outcomes Measurement Information System
or physical functioning in type SS sickle cell disease (HbSS).
Method
Subjects with HbSS (n = 21) and healthy subjects (n = 23) were randomized to daily oral doses (4,000 vs. 7,000 IU) of cholecalciferol
(vitamin D3) and evaluated at 6 and 12 weeks for changes in serum 25 hydroxyvitamin D (25(OH)D),
HRQL, and physical functioning.
Results
In subjects with HbSS, significant reductions in pain, fatigue, and depressive symptoms
and improved upper-extremity function were observed. In healthy subjects, significant
reductions in fatigue and improved upper-extremity function were observed. Significant
improvements in peak power and dorsiflexion isometric maximal voluntary contraction
torques were observed in both groups. In subjects with HbSS, improved plantar flexion
isometric maximal voluntary contraction torques were observed. Both groups saw significant
improvement in their total Bruininks-Oseretsky Test of Motor Proficiency score.
Discussion
Daily high-dose vitamin D supplementation for African American children with and without
HbSS improved HRQL and physical performance.
KEY WORDS
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Biography
Kelly A. Dougherty, Associate Professor, School of Health Sciences, Stockton University, Galloway, NJ.
Biography
Joan I. Schall, Associate Director, Nutrition and Growth Laboratory, Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA.
Biography
Chiara Bertolaso, Pediatric Resident, Department of Pediatrics, Johns Hopkins University, Baltimore, MD.
Biography
Kim Smith-Whitley, Director, Comprehensive Sickle Cell Center; Clinical Director, Division of Hematology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA; and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Biography
Virginia A. Stallings, Professor of Pediatrics, Director of the Nutrition Center, Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA; and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Article Info
Publication History
Published online: June 05, 2020
Footnotes
This study was supported by the National Center for Research Resources (grant no. UL1RR024134 ), which is now at the National Center for Advancing Translational Sciences (grant no. UL1TR000003 ), K12 (grant no. KL2RR024132 ), K23 (grant no. K23HL114637 ), and the Metabolism, Nutrition, and Development Research Affinity Group Pilot and Feasibility Grant, Gastroenterology Research and Education Fund Grant, and Nutrition Center at the Children's Hospital of Philadelphia .
Conflicts of interest: None to report.
Identification
Copyright
Copyright © 2020 by the National Association of Pediatric Nurse Practitioners. Published by Elsevier Inc. All rights reserved.
