Journal of Pediatric Health Care
Volume 21, Issue 2 , Pages 75-80 , March 2007

Meningococcemia: Epidemiology, Pathophysiology, and Management

  • Lisa M. Milonovich, RN, MSN, PCCNP, CCRN

      Affiliations

    • Corresponding Author InformationCorrespondence: Lisa M. Milonovich, RN, MSN, PCCNP, CCRN, Critical Care Services, Children’s Medical Center Dallas, 1935 Motor Street, Dallas, TX 75235

References 

  1. American Academy of Pediatrics. AAP endorses new meningococcal vaccine guidelines. 2005;Retrieved June 8 2005, from http://www.aap.org/advocacy/releases/may05mv.htm.
  2. American Academy of Pediatrics. Guillain-Barré cases among recipients of meningococcal conjugate vaccine: Interim guidance for physicians. 2005;Retrieved October, 14, 2005, from membership@listerv.aap.org.
  3. Bernard GR, Vincent JL, Laterre PF, LaRosa SP, Dhainaut JF, Lopez-Rodriquez A, et al. Efficacy and safety of recombinant human activated protein C for severe sepsis. New England Journal of Medicine. 2001;344:699–709
  4. Centers for Disease Control and Prevention. Meningococcal conjugate vaccine. 2005;Retrieved June 8 2005. from http://www.ckc.gov/nip/vaccine/mening/mcv4/mcv4_acip.htm.
  5. Eli Lilly Corporation. (letter) Discontinuation of Study F1K-MC-EVBP, investigation of the efficacy and safety of drotrecogin alfa(activated) in pediatric severe sepsis. 2005;Retrieved October 12, 2005, from http://www.pedsccm.com.
  6. Fischer M, Hilinski J, Stephens D. Adjuvant therapy for meningococcal sepsis. The Pediatric Infectious Disease Journal. 2005;24:177–178
  7. Healy CM, Baker CJ. The future of meningococcal vaccines. The Pediatric Infectious Disease Journal. 2005;24:175–176
  8. Kirsch EA, Barton RP, Kitchen L, Giroir BP. Pathophysiology, treatment and outcome of meningococcemia: A review and recent experience. The Pediatric Infectious Disease Journal. 1996;15:967–979
  9. Levin M, Quint PA, Goldstein B, Barton P, Bradley JS, Shemie SD, et al. Recombinant bactericidal/ permeability-increasing protein (rBPI21) as adjunctive treatment for children with severe meningococcal sepsis: A randomized trial. Lancet. 2000;356:961–967
  10. McIntyre PB, Berkey C, King SM, Schaad UB, Kilpi T, Kanra GY, et al. Dexamethasone as adjunctive therapy in bacterial meningitis: A meta-analysis of randomized clinical trials since 1988. JAMA. 1997;278:9925–9931
  11. Pathan N, Faust SN, Levin M. Pathophysiology of meningococcal meningitis and septicaemia. Archives of Diseases in Childhood. 2003;88:601–607
  12. Pichichero M, Casey J, Blatter M, Rothestein E, Ryall R, Bybel M, et al. Comparative trial of the safety and immunogenicity of quadrivalent (A,C, Y, W-135) meningococcal polysaccharide-diphtheria conjugate vaccine versus quadrivalent polysaccharide vaccine in two-to ten-year-old children. Pediatric Infectious Disease Journal. 2005;24:57–62
  13. Rosenstein NE, Perkins BA, Stephens DS, Popovic T, Hughes J. Medical progress: Meningococcal disease. New England Journal of Medicine. 2001;344:1378–1388
  14. Welch SB, Nadel S. Treatment of meningococcal infection. Arch Dis Child. 2003;88:608–614
  15. World Health Organization. Meningococcal meningitis (Fact Sheet). 2003;Retrieved June 7, 2005, from http://www.who.int/mediacentre/factsheets/fs141/en/print.html.
  16. Zaritsky AL, Nadkarni VM, Hickey RW, Schexnayder S, Berg RA. Pediatric Advanced Life Support provider manual. Dallas, TX: American Heart Association; 2002;

PII: S0891-5245(06)00278-1

doi: 10.1016/j.pedhc.2006.05.001

Journal of Pediatric Health Care
Volume 21, Issue 2 , Pages 75-80 , March 2007